| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 46 | 28/04/2012 | W | Southampton | 4 | Coventry | 0 | Current Table | |||
| 45 | 21/04/2012 | L | Middlesbrough | 2 | Southampton | 1 |  | (H) | 2nd | |
| 44 | 17/04/2012 | W | Peterborough | 1 | Southampton | 3 | | (H) | 2nd | |
| 43 | 13/04/2012 | L | Southampton | 1 | Reading | 3 | | (H) | 2nd | |
| 42 | 09/04/2012 | W | Crystal Palace | 0 | Southampton | 2 | | (H) | 1st | |
| 41 | 07/04/2012 | D | Southampton | 2 | Portsmouth | 2 | | (H) | 1st | |
| 40 | 31/03/2012 | L | Blackpool | 3 | Southampton | 0 | | (H) | 1st | |
| 39 | 24/03/2012 | W | Southampton | 2 | Doncaster | 0 | | (H) | 1st | |
| 38 | 20/03/2012 | W | Hull | 0 | Southampton | 2 | | (H) | 1st | |
| 37 | 17/03/2012 | W | Millwall | 2 | Southampton | 3 | | (H) | 1st | |
| 36 | 10/03/2012 | W | Southampton | 2 | Barnsley | 0 | | (H) | 1st | |
| 35 | 06/03/2012 | D | Southampton | 1 | Ipswich | 1 | | (H) | 1st | |
| 34 | 03/03/2012 | W | Leeds | 0 | Southampton | 1 | | (H) | 1st | |
| 33 | 25/02/2012 | W | Watford | 0 | Southampton | 3 | | (H) | 1st | |
| 32 | 18/02/2012 | W | Southampton | 4 | Derby | 0 | | (H) | 1st | |
| 31 | 14/02/2012 | D | West Ham | 1 | Southampton | 1 | | (H) | 2nd | |
| 30 | 11/02/2012 | W | Southampton | 2 | Burnley | 0 | | (H) | 2nd | |
| 29 | 04/02/2012 | D | Birmingham | 0 | Southampton | 0 | | (H) | 2nd | |
| 28 | 31/01/2012 | D | Southampton | 1 | Cardiff | 1 | | (H) | 2nd | |
| 27 | 23/01/2012 | L | Southampton | 0 | Leicester | 2 | | (H) | 2nd | |
| 26 | 14/01/2012 | W | Nottm Forest | 0 | Southampton | 3 | | (H) | 1st | |
| 25 | 02/01/2012 | L | Brighton | 3 | Southampton | 0 | | (H) | 1st | |
| 24 | 30/12/2011 | L | Southampton | 0 | Bristol City | 1 | | (H) | 1st | |
| 23 | 26/12/2011 | W | Southampton | 2 | Crystal Palace | 0 | | (H) | 1st | |
| 22 | 18/12/2011 | D | Portsmouth | 1 | Southampton | 1 | | (H) | 1st | |
| 21 | 10/12/2011 | D | Southampton | 2 | Blackpool | 2 | | (H) | 1st | |
| 20 | 03/12/2011 | L | Doncaster | 1 | Southampton | 0 | | (H) | 1st | |
| 19 | 29/11/2011 | W | Southampton | 2 | Hull | 1 | | (H) | 1st | |
| 18 | 26/11/2011 | L | Bristol City | 2 | Southampton | 0 | | (H) | 1st | |
| 17 | 19/11/2011 | W | Southampton | 3 | Brighton | 0 | | (H) | 1st | |
| 16 | 05/11/2011 | W | Coventry | 2 | Southampton | 4 | | (H) | 1st | |
| 15 | 01/11/2011 | W | Southampton | 2 | Peterborough | 1 | | (H) | 1st | |
| 14 | 29/10/2011 | W | Southampton | 3 | Middlesbrough | 0 | | (H) | 1st | |
| 13 | 22/10/2011 | D | Reading | 1 | Southampton | 1 | | (H) | 1st | |
| 12 | 18/10/2011 | W | Southampton | 1 | West Ham | 0 | | (H) | 1st | |
| 11 | 15/10/2011 | D | Derby | 1 | Southampton | 1 | | (H) | 1st | |
| 10 | 01/10/2011 | W | Southampton | 4 | Watford | 0 | | (H) | 1st | |
| 9 | 28/09/2011 | L | Cardiff | 2 | Southampton | 1 | | (H) | 1st | |
| 8 | 24/09/2011 | D | Burnley | 1 | Southampton | 1 | | (H) | 1st | |
| 7 | 18/09/2011 | W | Southampton | 4 | Birmingham | 1 | | (H) | 1st | |
| 6 | 10/09/2011 | W | Southampton | 3 | Nottm Forest | 2 | | (H) | 2nd | |
| 5 | 27/08/2011 | L | Leicester | 3 | Southampton | 2 | | (H) | 2nd | |
| 4 | 20/08/2011 | W | Southampton | 1 | Millwall | 0 | | (H) | 1st | |
| 3 | 16/08/2011 | W | Ipswich | 2 | Southampton | 5 | | (H) | 1st | |
| 2 | 13/08/2011 | W | Barnsley | 0 | Southampton | 1 | | (H) | 2nd | |
| 1 | 06/08/2011 | W | Southampton | 3 | Leeds | 1 | | (H) | 2nd | |
