| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 46 | 05/05/2012 | D | Tranmere | 1 | Scunthorpe | 1 | Current Table | |||
| 45 | 28/04/2012 | L | Colchester | 4 | Tranmere | 2 |  | (H) | 13th |  |
| 44 | 21/04/2012 | D | Tranmere | 1 | Hartlepool | 1 | | (H) | 11th | |
| 43 | 14/04/2012 | W | Walsall | 0 | Tranmere | 1 | | (H) | 11th | |
| 42 | 09/04/2012 | L | Milton Keynes Dons | 3 | Tranmere | 0 | | (H) | 13th | |
| 41 | 06/04/2012 | W | Tranmere | 3 | Stevenage | 0 | | (H) | 11th | |
| 40 | 31/03/2012 | L | Bury | 2 | Tranmere | 0 |  | (H) | 13th | |
| 39 | 24/03/2012 | W | Tranmere | 2 | Exeter | 0 | | (H) | 12th | |
| 38 | 20/03/2012 | W | Rochdale | 0 | Tranmere | 2 | | (H) | 15th | |
| 37 | 17/03/2012 | D | Sheff Utd | 1 | Tranmere | 1 | | (H) | 16th | |
| 36 | 13/03/2012 | W | Tranmere | 2 | Preston | 1 | | (H) | 16th | |
| 35 | 10/03/2012 | W | Tranmere | 2 | Leyton Orient | 0 | | (H) | 19th | |
| 34 | 06/03/2012 | D | Tranmere | 1 | Notts County | 1 | | (H) | 20th | |
| 33 | 03/03/2012 | L | Chesterfield | 1 | Tranmere | 0 | | (H) | 19th | |
| 32 | 25/02/2012 | L | Oldham | 1 | Tranmere | 0 | | (H) | 17th | |
| 31 | 18/02/2012 | D | Tranmere | 1 | Charlton | 1 | | (H) | 17th | |
| 30 | 14/02/2012 | D | Carlisle | 0 | Tranmere | 0 | | (H) | 17th | |
| 29 | 04/02/2012 | L | Wycombe | 2 | Tranmere | 1 | | (H) | 17th | |
| 28 | 28/01/2012 | D | Tranmere | 1 | Huddersfield | 1 | | (H) | 17th | |
| 27 | 21/01/2012 | L | Bournemouth | 2 | Tranmere | 1 | | (H) | 17th | |
| 26 | 17/01/2012 | D | Tranmere | 0 | Rochdale | 0 | | (H) | 16th | |
| 25 | 14/01/2012 | L | Yeovil | 2 | Tranmere | 1 | | (H) | 17th | |
| 24 | 07/01/2012 | D | Tranmere | 2 | Brentford | 2 | | (H) | 17th | |
| 23 | 02/01/2012 | L | Sheff Wed | 2 | Tranmere | 1 | | (H) | 16th | |
| 22 | 30/12/2011 | W | Tranmere | 2 | Bury | 0 | | (H) | 15th | |
| 21 | 17/12/2011 | L | Stevenage | 2 | Tranmere | 1 | | (H) | 15th | |
| 20 | 10/12/2011 | L | Tranmere | 0 | Milton Keynes Dons | 2 | | (H) | 15th | |
| 19 | 26/11/2011 | L | Exeter | 3 | Tranmere | 0 | | (H) | 12th | |
| 18 | 19/11/2011 | L | Tranmere | 1 | Sheff Wed | 2 | | (H) | 8th | |
| 17 | 05/11/2011 | D | Tranmere | 0 | Colchester | 0 | | (H) | 8th | |
| 16 | 29/10/2011 | L | Scunthorpe | 4 | Tranmere | 2 | | (H) | 7th | |
| 15 | 25/10/2011 | W | Hartlepool | 0 | Tranmere | 2 | | (H) | 6th | |
| 14 | 22/10/2011 | W | Tranmere | 2 | Walsall | 1 | | (H) | 8th | |
| 13 | 15/10/2011 | W | Tranmere | 1 | Oldham | 0 | | (H) | 11th | |
| 12 | 08/10/2011 | D | Charlton | 1 | Tranmere | 1 | | (H) | 13th | |
| 11 | 01/10/2011 | D | Tranmere | 0 | Bournemouth | 0 | | (H) | 12th | |
| 10 | 24/09/2011 | L | Preston | 2 | Tranmere | 1 | | (H) | 11th | |
| 9 | 17/09/2011 | W | Tranmere | 2 | Wycombe | 0 | | (H) | 10th | |
| 8 | 13/09/2011 | L | Tranmere | 1 | Carlisle | 2 | | (H) | 12th | |
| 7 | 10/09/2011 | L | Huddersfield | 2 | Tranmere | 0 | | (H) | 10th | |
| 6 | 03/09/2011 | D | Tranmere | 0 | Yeovil | 0 | | (H) | 5th | |
| 5 | 27/08/2011 | W | Brentford | 0 | Tranmere | 2 | | (H) | 5th | |
| 4 | 20/08/2011 | D | Tranmere | 1 | Sheff Utd | 1 | | (H) | 7th | |
| 3 | 16/08/2011 | L | Notts County | 3 | Tranmere | 2 | | (H) | 6th | |
| 2 | 13/08/2011 | W | Leyton Orient | 0 | Tranmere | 1 | | (H) | 3rd | |
| 1 | 06/08/2011 | W | Tranmere | 1 | Chesterfield | 0 | | (H) | 7th | |
