| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 48 | 16/05/2012 | D | Southend | 2 | Crewe | 2 | ||||
| 47 | 12/05/2012 | L | Crewe | 1 | Southend | 0 | ||||
| 46 | 05/05/2012 | W | Southend | 2 | Macclesfield | 0 |  | (H) | 4th | |
| 45 | 28/04/2012 | W | Oxford Utd | 0 | Southend | 2 | | |||
| 44 | 20/04/2012 | W | Southend | 3 | Barnet | 0 | | (H) | 5th | |
| 43 | 14/04/2012 | D | Torquay | 0 | Southend | 0 |  | (H) | 5th | |
| 42 | 09/04/2012 | W | Southend | 2 | AFC Wimbledon | 0 | | (H) | 5th | |
| 41 | 06/04/2012 | L | Bradford | 2 | Southend | 0 | | (H) | 5th | |
| 40 | 30/03/2012 | W | Southend | 4 | Cheltenham | 0 |  | (H) | 5th | |
| 39 | 24/03/2012 | L | Bristol Rovers | 1 | Southend | 0 | | (H) | 5th | |
| 38 | 20/03/2012 | L | Southend | 0 | Aldershot | 1 | | (H) | 4th | |
| 37 | 17/03/2012 | W | Hereford | 2 | Southend | 3 | | (H) | 3rd | |
| 36 | 10/03/2012 | D | Southend | 2 | Accrington Stanley | 2 | | |||
| 35 | 05/03/2012 | D | Southend | 0 | Crawley Town | 0 | | (H) | 3rd | |
| 34 | 03/03/2012 | W | Burton Albion | 0 | Southend | 2 | | |||
| 33 | 25/02/2012 | L | Morecambe | 1 | Southend | 0 | | (H) | 3rd | |
| 32 | 21/02/2012 | L | Aldershot | 2 | Southend | 0 | | (H) | 3rd | |
| 31 | 18/02/2012 | W | Southend | 1 | Crewe | 0 | | (H) | 1st | |
| 30 | 13/02/2012 | W | Gillingham | 1 | Southend | 2 | | (H) | 1st | |
| 29 | 10/02/2012 | L | Southend | 0 | Rotherham | 2 | | (H) | 3rd | |
| 28 | 04/02/2012 | D | Plymouth | 2 | Southend | 2 | | (H) | 2nd | |
| 27 | 31/01/2012 | L | Southend | 1 | Swindon | 4 | | (H) | 3rd | |
| 26 | 21/01/2012 | L | Shrewsbury | 2 | Southend | 1 | | (H) | 1st | |
| 25 | 14/01/2012 | W | Northampton | 2 | Southend | 5 | | (H) | 1st | |
| 24 | 07/01/2012 | W | Southend | 3 | Port Vale | 0 | | (H) | 2nd | |
| 23 | 02/01/2012 | D | Southend | 1 | Dagenham and Redbridge | 1 | | (H) | 3rd | |
| 22 | 31/12/2011 | W | AFC Wimbledon | 1 | Southend | 4 | | (H) | 3rd | |
| 21 | 16/12/2011 | L | Southend | 0 | Bradford | 1 | | (H) | 2nd | |
| 20 | 10/12/2011 | L | Cheltenham | 3 | Southend | 0 | | (H) | 2nd | |
| 19 | 26/11/2011 | D | Southend | 1 | Bristol Rovers | 1 | | (H) | 1st | |
| 18 | 19/11/2011 | W | Dagenham and Redbridge | 2 | Southend | 3 | | (H) | 1st | |
| 17 | 05/11/2011 | W | Southend | 2 | Oxford Utd | 1 | | (H) | 1st | |
| 16 | 29/10/2011 | W | Macclesfield | 0 | Southend | 2 | | (H) | 1st | |
| 15 | 25/10/2011 | W | Barnet | 0 | Southend | 3 | | (H) | 2nd | |
| 14 | 22/10/2011 | W | Southend | 4 | Torquay | 1 | | (H) | 2nd | |
| 13 | 15/10/2011 | D | Southend | 1 | Morecambe | 1 | | (H) | 2nd | |
| 12 | 08/10/2011 | W | Crewe | 1 | Southend | 3 | | (H) | 1st | |
| 11 | 30/09/2011 | W | Southend | 3 | Shrewsbury | 0 | | (H) | 1st | |
| 10 | 24/09/2011 | W | Rotherham | 0 | Southend | 4 | | (H) | 3rd | |
| 9 | 17/09/2011 | W | Southend | 2 | Plymouth | 0 | | (H) | 6th | |
| 8 | 13/09/2011 | W | Southend | 1 | Gillingham | 0 | | (H) | 9th | |
| 7 | 10/09/2011 | L | Swindon | 2 | Southend | 0 | | (H) | 12th | |
| 6 | 03/09/2011 | D | Southend | 2 | Northampton | 2 | | (H) | 9th | |
| 5 | 27/08/2011 | W | Port Vale | 2 | Southend | 3 | | (H) | 7th | |
| 4 | 20/08/2011 | L | Southend | 0 | Burton Albion | 1 | | (H) | 13th | |
| 3 | 16/08/2011 | L | Crawley Town | 3 | Southend | 0 | | (H) | 9th | |
| 2 | 13/08/2011 | W | Accrington Stanley | 1 | Southend | 2 | | (H) | 3rd | |
| 1 | 06/08/2011 | W | Southend | 1 | Hereford | 0 | | (H) | 8th | |
