| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 34 | 05/05/2012 | L | Mainz | 0 | Borussia Monchengladbach | 3 | Current Table | |||
| 33 | 28/04/2012 | D | Hamburg | 0 | Mainz | 0 |  | (H) | 13th |  |
| 32 | 20/04/2012 | D | Mainz | 0 | Wolfsburg | 0 | | (H) | 12th | |
| 31 | 14/04/2012 | D | Bayern Munich | 0 | Mainz | 0 | | (H) | 12th | |
| 30 | 10/04/2012 | W | Mainz | 4 | FC Koln | 0 | | (H) | 11th | |
| 29 | 07/04/2012 | L | VfB Stuttgart | 4 | Mainz | 1 | | (H) | 11th | |
| 28 | 31/03/2012 | W | Werder Bremen | 0 | Mainz | 3 |  | (H) | 11th | |
| 27 | 24/03/2012 | L | Mainz | 1 | Hertha Berlin | 3 | | (H) | 12th | |
| 26 | 17/03/2012 | L | Augsburg | 2 | Mainz | 1 | | (H) | 11th | |
| 25 | 10/03/2012 | W | Mainz | 2 | Nurnberg | 1 | | (H) | 11th | |
| 24 | 03/03/2012 | L | Borussia Dortmund | 2 | Mainz | 1 | | (H) | 12th | |
| 23 | 25/02/2012 | W | Mainz | 4 | Kaiserslautern | 0 | | (H) | 11th | |
| 22 | 17/02/2012 | D | Hoffenheim | 1 | Mainz | 1 | | (H) | 13th | |
| 21 | 11/02/2012 | D | Mainz | 1 | Hannover 96 | 1 | | (H) | 13th | |
| 20 | 04/02/2012 | D | Schalke 04 | 1 | Mainz | 1 | | (H) | 13th | |
| 19 | 29/01/2012 | W | Mainz | 3 | Freiburg | 1 | | (H) | 12th | |
| 18 | 22/01/2012 | L | Bayer Leverkusen | 3 | Mainz | 2 | | (H) | 15th | |
| 17 | 18/12/2011 | L | Borussia Monchengladbach | 1 | Mainz | 0 | | (H) | 14th | |
| 16 | 13/12/2011 | D | FC Koln | 1 | Mainz | 1 | | (H) | 12th | |
| 15 | 10/12/2011 | D | Mainz | 0 | Hamburg | 0 | | (H) | 13th | |
| 14 | 03/12/2011 | D | Wolfsburg | 2 | Mainz | 2 | | (H) | 14th | |
| 13 | 27/11/2011 | W | Mainz | 3 | Bayern Munich | 2 | | (H) | 13th | |
| 12 | 04/11/2011 | W | Mainz | 3 | VfB Stuttgart | 1 | | (H) | 14th | |
| 11 | 29/10/2011 | L | Mainz | 1 | Werder Bremen | 3 | | (H) | 15th | |
| 10 | 22/10/2011 | D | Hertha Berlin | 0 | Mainz | 0 | | (H) | 15th | |
| 9 | 15/10/2011 | L | Mainz | 0 | Augsburg | 1 | | (H) | 15th | |
| 8 | 01/10/2011 | D | Nurnberg | 3 | Mainz | 3 | | (H) | 14th | |
| 7 | 24/09/2011 | L | Mainz | 1 | Borussia Dortmund | 2 | | (H) | 14th | |
| 6 | 17/09/2011 | L | Kaiserslautern | 3 | Mainz | 1 | | (H) | 13th | |
| 5 | 10/09/2011 | L | Mainz | 0 | Hoffenheim | 4 | | (H) | 12th | |
| 4 | 28/08/2011 | D | Hannover 96 | 1 | Mainz | 1 | | (H) | 7th | |
| 3 | 21/08/2011 | L | Mainz | 2 | Schalke 04 | 4 | | (H) | 8th | |
| 2 | 13/08/2011 | W | Freiburg | 1 | Mainz | 2 | | (H) | 1st | |
| 1 | 07/08/2011 | W | Mainz | 2 | Bayer Leverkusen | 0 | | (H) | 4th | |
