| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 30 | 22/04/2012 | L | OFI Crete | 0 | PAS Giannina | 2 |  | (H) | 10th |  |
| 29 | 18/04/2012 | L | Kerkyra | 4 | OFI Crete | 1 | | (H) | 8th | |
| 28 | 08/04/2012 | W | OFI Crete | 1 | Panaitolikos | 0 | | (H) | 8th | |
| 27 | 01/04/2012 | D | Asteras Tripoli | 2 | OFI Crete | 2 | | (H) | 8th | |
| 26 | 24/03/2012 | L | OFI Crete | 0 | Panathinaikos | 1 | | (H) | 8th | |
| 25 | 17/03/2012 | L | Aris Salonika | 1 | OFI Crete | 0 | | (H) | 8th | |
| 24 | 10/03/2012 | L | OFI Crete | 0 | Panionios | 1 | | (H) | 7th | |
| 23 | 04/03/2012 | L | OFI Crete | 0 | Olympiacos | 2 | | (H) | 8th | |
| 22 | 26/02/2012 | D | AEK Athens | 1 | OFI Crete | 1 | | (H) | 6th | |
| 21 | 11/02/2012 | L | OFI Crete | 0 | PAOK Salonika | 2 | | (H) | 5th | |
| 20 | 04/02/2012 | W | Ergotelis | 0 | OFI Crete | 1 | | (H) | 5th | |
| 19 | 28/01/2012 | W | OFI Crete | 1 | Xanthi | 0 | | (H) | 6th | |
| 18 | 22/01/2012 | W | Levadiakos | 0 | OFI Crete | 2 | | (H) | 7th | |
| 17 | 14/01/2012 | W | OFI Crete | 2 | Doxa Dramas | 0 | | (H) | 7th | |
| 16 | 08/01/2012 | L | Atromitos | 2 | OFI Crete | 0 | | (H) | 8th | |
| 15 | 03/01/2012 | D | PAS Giannina | 0 | OFI Crete | 0 | | (H) | 7th | |
| 14 | 28/12/2011 | L | OFI Crete | 0 | Levadiakos | 1 | | (H) | 7th | |
| 13 | 18/12/2011 | D | OFI Crete | 0 | Kerkyra | 0 | | (H) | 7th | |
| 12 | 11/12/2011 | L | Panaitolikos | 1 | OFI Crete | 0 | | (H) | 7th | |
| 11 | 07/12/2011 | W | Doxa Dramas | 0 | OFI Crete | 1 | | (H) | 5th | |
| 10 | 03/12/2011 | W | OFI Crete | 3 | Asteras Tripoli | 0 | | (H) | 7th | |
| 9 | 27/11/2011 | L | Panathinaikos | 3 | OFI Crete | 1 | | (H) | 7th | |
| 8 | 20/11/2011 | L | OFI Crete | 0 | Aris Salonika | 1 | | (H) | 6th | |
| 7 | 05/11/2011 | W | Panionios | 1 | OFI Crete | 3 | | (H) | 5th | |
| 6 | 29/10/2011 | D | Olympiacos | 2 | OFI Crete | 2 | | (H) | 7th | |
| 5 | 23/10/2011 | W | OFI Crete | 3 | AEK Athens | 1 | | (H) | 7th | |
| 4 | 16/10/2011 | D | PAOK Salonika | 0 | OFI Crete | 0 | | (H) | 9th | |
| 3 | 01/10/2011 | W | OFI Crete | 1 | Ergotelis | 0 | | (H) | 10th | |
| 2 | 25/09/2011 | L | Xanthi | 3 | OFI Crete | 1 |  | (H) | 13th | |
| 1 | 27/08/2011 | D | OFI Crete | 1 | Atromitos | 1 | | (H) | 6th | |
