| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 30 | 22/04/2012 | W | Xanthi | 4 | Ergotelis | 2 |  | (H) | 11th |  |
| 29 | 18/04/2012 | D | Panionios | 1 | Xanthi | 1 | | (H) | 11th | |
| 28 | 09/04/2012 | L | Levadiakos | 2 | Xanthi | 0 | | (H) | 11th | |
| 27 | 01/04/2012 | W | Xanthi | 1 | Doxa Dramas | 0 | | (H) | 11th | |
| 26 | 24/03/2012 | L | Atromitos | 1 | Xanthi | 0 | | (H) | 10th | |
| 25 | 18/03/2012 | L | Xanthi | 1 | PAS Giannina | 2 | | (H) | 10th | |
| 24 | 11/03/2012 | L | Kerkyra | 2 | Xanthi | 0 | | (H) | 9th | |
| 23 | 03/03/2012 | L | Xanthi | 0 | Panaitolikos | 1 | | (H) | 9th | |
| 22 | 18/02/2012 | L | Xanthi | 0 | Asteras Tripoli | 1 |  | (H) | 9th | |
| 21 | 12/02/2012 | L | Panathinaikos | 3 | Xanthi | 0 | | (H) | 8th | |
| 20 | 05/02/2012 | L | Xanthi | 0 | Aris Salonika | 2 | | (H) | 6th | |
| 19 | 28/01/2012 | L | OFI Crete | 1 | Xanthi | 0 | | (H) | 5th | |
| 18 | 22/01/2012 | W | Xanthi | 1 | Olympiacos | 0 | | (H) | 5th | |
| 17 | 14/01/2012 | D | AEK Athens | 1 | Xanthi | 1 | | (H) | 6th | |
| 16 | 08/01/2012 | D | Xanthi | 0 | PAOK Salonika | 0 | | (H) | 6th | |
| 15 | 04/01/2012 | W | Ergotelis | 1 | Xanthi | 2 | | (H) | 5th | |
| 14 | 17/12/2011 | W | Xanthi | 1 | Panionios | 0 | | (H) | 6th | |
| 13 | 10/12/2011 | D | Xanthi | 1 | Levadiakos | 1 | | (H) | 6th | |
| 12 | 04/12/2011 | W | Doxa Dramas | 0 | Xanthi | 2 | | (H) | 5th | |
| 11 | 27/11/2011 | W | Xanthi | 3 | Atromitos | 0 | | (H) | 6th | |
| 10 | 20/11/2011 | W | PAS Giannina | 0 | Xanthi | 2 | | (H) | 7th | |
| 9 | 06/11/2011 | W | Xanthi | 1 | Kerkyra | 0 | | (H) | 10th | |
| 8 | 29/10/2011 | L | Panaitolikos | 2 | Xanthi | 0 | | (H) | 11th | |
| 7 | 22/10/2011 | D | Asteras Tripoli | 1 | Xanthi | 1 | | (H) | 10th | |
| 6 | 16/10/2011 | L | Xanthi | 2 | Panathinaikos | 3 | | (H) | 11th | |
| 5 | 02/10/2011 | D | Aris Salonika | 0 | Xanthi | 0 | | (H) | 9th | |
| 4 | 25/09/2011 | W | Xanthi | 3 | OFI Crete | 1 | | (H) | 10th | |
| 3 | 21/09/2011 | L | Xanthi | 3 | AEK Athens | 4 | | (H) | 16th | |
| 2 | 18/09/2011 | L | Olympiacos | 2 | Xanthi | 1 | | (H) | 16th | |
| 1 | 28/08/2011 | L | PAOK Salonika | 1 | Xanthi | 0 | | (H) | 15th | |
