| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 38 | 13/05/2012 | L | Napoli | 2 | Siena | 1 |  | (H) | 14th |  |
| 37 | 06/05/2012 | L | Siena | 0 | Parma | 2 | | (H) | 14th | |
| 36 | 02/05/2012 | D | Lazio | 1 | Siena | 1 | | (H) | 13th | |
| 35 | 29/04/2012 | L | Siena | 1 | AC Milan | 4 | | (H) | 13th | |
| 34 | 25/04/2012 | D | Siena | 1 | Bologna | 1 | | (H) | 10th | |
| 33 | 22/04/2012 | W | Genoa | 1 | Siena | 4 | | (H) | 10th | |
| 32 | 11/04/2012 | L | Inter Milan | 2 | Siena | 1 | | (H) | 13th | |
| 31 | 07/04/2012 | W | Atalanta | 1 | Siena | 2 | | (H) | 10th | |
| 30 | 01/04/2012 | W | Siena | 1 | Udinese | 0 | | (H) | 13th | |
| 29 | 25/03/2012 | D | Chievo | 1 | Siena | 1 |  | (H) | 15th | |
| 28 | 18/03/2012 | L | Siena | 0 | Novara | 2 | | (H) | 15th | |
| 27 | 11/03/2012 | W | Cesena | 0 | Siena | 2 | | (H) | 14th | |
| 26 | 04/03/2012 | W | Siena | 3 | Cagliari | 0 | | (H) | 16th | |
| 25 | 26/02/2012 | W | Siena | 4 | Palermo | 1 | | (H) | 17th | |
| 24 | 22/02/2012 | L | Siena | 0 | Catania | 1 | | (H) | 17th | |
| 23 | 19/02/2012 | L | Lecce | 4 | Siena | 1 | | (H) | 17th | |
| 22 | 13/02/2012 | W | Siena | 1 | Roma | 0 | | (H) | 16th | |
| 21 | 05/02/2012 | D | Juventus | 0 | Siena | 0 | | (H) | 17th | |
| 20 | 29/01/2012 | L | Fiorentina | 2 | Siena | 1 | | (H) | 17th | |
| 19 | 22/01/2012 | D | Siena | 1 | Napoli | 1 | | (H) | 17th | |
| 18 | 15/01/2012 | L | Parma | 3 | Siena | 1 | | (H) | 17th | |
| 17 | 07/01/2012 | W | Siena | 4 | Lazio | 0 | | (H) | 16th | |
| 16 | 20/12/2011 | D | Siena | 0 | Fiorentina | 0 | | (H) | 16th | |
| 15 | 17/12/2011 | L | AC Milan | 2 | Siena | 0 | | (H) | 17th | |
| 14 | 10/12/2011 | L | Siena | 0 | Genoa | 2 | | (H) | 17th | |
| 13 | 04/12/2011 | L | Bologna | 1 | Siena | 0 | | (H) | 15th | |
| 12 | 27/11/2011 | L | Siena | 0 | Inter Milan | 1 | | (H) | 12th | |
| 11 | 20/11/2011 | D | Siena | 2 | Atalanta | 2 | | (H) | 11th | |
| 10 | 06/11/2011 | L | Udinese | 2 | Siena | 1 | | (H) | 9th | |
| 9 | 30/10/2011 | W | Siena | 4 | Chievo | 1 | | (H) | 7th | |
| 8 | 26/10/2011 | D | Novara | 1 | Siena | 1 | | (H) | 11th | |
| 7 | 23/10/2011 | W | Siena | 2 | Cesena | 0 | | (H) | 11th | |
| 6 | 16/10/2011 | D | Cagliari | 0 | Siena | 0 | | (H) | 14th | |
| 5 | 02/10/2011 | L | Palermo | 2 | Siena | 0 | | (H) | 14th | |
| 4 | 25/09/2011 | W | Siena | 3 | Lecce | 0 | | (H) | 9th | |
| 3 | 22/09/2011 | D | Roma | 1 | Siena | 1 | | (H) | 15th | |
| 2 | 18/09/2011 | L | Siena | 0 | Juventus | 1 | | (H) | 16th | |
| 1 | 11/09/2011 | D | Catania | 0 | Siena | 0 | | (H) | 13th | |
