| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 46 | 09/06/2012 | W | Varese | 0 | Sampdoria | 1 | ||||
| 45 | 06/06/2012 | W | Sampdoria | 3 | Varese | 2 | ||||
| 44 | 02/06/2012 | D | Sassuolo | 1 | Sampdoria | 1 | ||||
| 43 | 30/05/2012 | W | Sampdoria | 2 | Sassuolo | 1 | ||||
| 42 | 26/05/2012 | L | Varese | 3 | Sampdoria | 1 |  | (H) | 6th |  |
| 41 | 20/05/2012 | L | Sampdoria | 1 | Pescara | 3 | | (H) | 6th | |
| 40 | 12/05/2012 | W | Juve Stabia | 1 | Sampdoria | 2 | | (H) | 6th | |
| 39 | 06/05/2012 | W | Sampdoria | 3 | Reggina | 1 | | (H) | 6th | |
| 38 | 01/05/2012 | W | Modena | 0 | Sampdoria | 2 | | (H) | 6th | |
| 37 | 28/04/2012 | W | Sampdoria | 2 | Bari | 0 | | (H) | 6th | |
| 36 | 21/04/2012 | D | Vicenza | 1 | Sampdoria | 1 | | (H) | 8th | |
| 35 | 14/04/2012 | W | Sampdoria | 2 | Brescia | 0 | | (H) | 7th | |
| 34 | 06/04/2012 | L | Crotone | 1 | Sampdoria | 0 | | (H) | 8th | |
| 33 | 31/03/2012 | W | Sampdoria | 2 | Nocerina | 0 |  | (H) | 7th | |
| 32 | 24/03/2012 | W | Cittadella | 1 | Sampdoria | 2 | | (H) | 8th | |
| 31 | 17/03/2012 | D | Sampdoria | 0 | Ascoli | 0 | | (H) | 8th | |
| 30 | 10/03/2012 | D | Sassuolo | 0 | Sampdoria | 0 | | (H) | 9th | |
| 29 | 06/03/2012 | W | Sampdoria | 1 | Empoli | 0 | | (H) | 8th | |
| 28 | 03/03/2012 | W | Sampdoria | 2 | Hellas Verona | 0 | | (H) | 11th | |
| 27 | 20/02/2012 | L | Torino | 2 | Sampdoria | 1 | | (H) | 11th | |
| 26 | 11/02/2012 | W | Sampdoria | 1 | Albinoleffe | 0 | | (H) | 10th | |
| 25 | 04/02/2012 | W | Grosseto | 0 | Sampdoria | 1 | | (H) | 11th | |
| 24 | 28/01/2012 | D | Gubbio | 0 | Sampdoria | 0 | | (H) | 12th | |
| 23 | 20/01/2012 | D | Sampdoria | 1 | Livorno | 1 | | (H) | 12th | |
| 22 | 14/01/2012 | W | Padova | 1 | Sampdoria | 2 | | (H) | 10th | |
| 21 | 06/01/2012 | L | Sampdoria | 0 | Varese | 1 | | (H) | 12th | |
| 20 | 19/12/2011 | L | Pescara | 1 | Sampdoria | 0 | | (H) | 11th | |
| 19 | 09/12/2011 | D | Sampdoria | 1 | Juve Stabia | 1 | | (H) | 10th | |
| 18 | 03/12/2011 | D | Reggina | 0 | Sampdoria | 0 | | (H) | 10th | |
| 17 | 26/11/2011 | D | Sampdoria | 1 | Modena | 1 | | (H) | 9th | |
| 16 | 19/11/2011 | D | Bari | 1 | Sampdoria | 1 | | (H) | 7th | |
| 15 | 13/11/2011 | L | Sampdoria | 0 | Vicenza | 1 | | (H) | 7th | |
| 14 | 07/11/2011 | D | Brescia | 0 | Sampdoria | 0 | | (H) | 6th | |
| 13 | 01/11/2011 | W | Sampdoria | 2 | Crotone | 0 | | (H) | 6th | |
| 12 | 29/10/2011 | L | Nocerina | 4 | Sampdoria | 2 | | (H) | 6th | |
| 11 | 22/10/2011 | D | Sampdoria | 0 | Cittadella | 0 | | (H) | 6th | |
| 10 | 15/10/2011 | W | Ascoli | 1 | Sampdoria | 2 | | (H) | 4th | |
| 9 | 09/10/2011 | D | Sampdoria | 1 | Sassuolo | 1 | | (H) | 7th | |
| 8 | 05/10/2011 | D | Hellas Verona | 1 | Sampdoria | 1 | | (H) | 6th | |
| 7 | 30/09/2011 | L | Sampdoria | 1 | Torino | 2 | | (H) | 6th | |
| 6 | 24/09/2011 | W | Albinoleffe | 1 | Sampdoria | 3 | | (H) | 4th | |
| 5 | 17/09/2011 | D | Sampdoria | 0 | Grosseto | 0 | | (H) | 7th | |
| 4 | 12/09/2011 | W | Empoli | 1 | Sampdoria | 3 | | (H) | 6th | |
| 3 | 04/09/2011 | W | Sampdoria | 6 | Gubbio | 0 | | (H) | 7th | |
| 2 | 30/08/2011 | D | Livorno | 0 | Sampdoria | 0 | | (H) | 14th | |
| 1 | 25/08/2011 | D | Sampdoria | 2 | Padova | 2 | | (H) | 3rd | |
