| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 44 | 02/06/2012 | D | Sassuolo | 1 | Sampdoria | 1 | ||||
| 43 | 30/05/2012 | L | Sampdoria | 2 | Sassuolo | 1 | ||||
| 42 | 26/05/2012 | W | Juve Stabia | 1 | Sassuolo | 3 |  | (H) | 3rd | |
| 41 | 20/05/2012 | W | Sassuolo | 4 | Reggina | 1 | | (H) | 3rd | |
| 40 | 15/05/2012 | L | Torino | 3 | Sassuolo | 0 | | (H) | 3rd | |
| 39 | 12/05/2012 | D | Livorno | 0 | Sassuolo | 0 | | (H) | 2nd | |
| 38 | 05/05/2012 | W | Sassuolo | 2 | Crotone | 0 | | (H) | 3rd | |
| 37 | 01/05/2012 | W | Padova | 0 | Sassuolo | 2 | | (H) | 3rd | |
| 36 | 27/04/2012 | W | Brescia | 1 | Sassuolo | 2 | | (H) | 3rd | |
| 35 | 21/04/2012 | L | Sassuolo | 0 | Gubbio | 2 | | (H) | 4th | |
| 34 | 06/04/2012 | D | Sassuolo | 0 | Modena | 0 | | (H) | 1st | |
| 33 | 31/03/2012 | D | Grosseto | 2 | Sassuolo | 2 |  | (H) | 2nd | |
| 32 | 23/03/2012 | W | Sassuolo | 1 | Empoli | 0 | | (H) | 2nd | |
| 31 | 17/03/2012 | W | Albinoleffe | 2 | Sassuolo | 3 | | (H) | 4th | |
| 30 | 10/03/2012 | D | Sassuolo | 0 | Sampdoria | 0 | | (H) | 4th | |
| 29 | 03/03/2012 | L | Pescara | 3 | Sassuolo | 2 | | (H) | 3rd | |
| 28 | 25/02/2012 | D | Sassuolo | 0 | Ascoli | 0 | | (H) | 2nd | |
| 27 | 18/02/2012 | D | Sassuolo | 0 | Varese | 0 | | (H) | 1st | |
| 26 | 12/02/2012 | W | Bari | 1 | Sassuolo | 2 | | (H) | 1st | |
| 25 | 31/01/2012 | D | Cittadella | 0 | Sassuolo | 0 | | (H) | 2nd | |
| 24 | 28/01/2012 | W | Sassuolo | 2 | Hellas Verona | 0 | | (H) | 1st | |
| 23 | 21/01/2012 | W | Sassuolo | 4 | Vicenza | 2 | | (H) | 1st | |
| 22 | 13/01/2012 | W | Nocerina | 0 | Sassuolo | 1 | | (H) | 2nd | |
| 21 | 06/01/2012 | W | Sassuolo | 2 | Juve Stabia | 1 | | (H) | 3rd | |
| 20 | 17/12/2011 | D | Reggina | 1 | Sassuolo | 1 | | (H) | 3rd | |
| 19 | 10/12/2011 | W | Sassuolo | 2 | Livorno | 1 | | (H) | 3rd | |
| 18 | 03/12/2011 | D | Crotone | 1 | Sassuolo | 1 | | (H) | 4th | |
| 17 | 26/11/2011 | L | Sassuolo | 0 | Padova | 1 | | (H) | 3rd | |
| 16 | 19/11/2011 | D | Sassuolo | 1 | Brescia | 1 | | (H) | 3rd | |
| 15 | 13/11/2011 | W | Gubbio | 0 | Sassuolo | 1 | | (H) | 2nd | |
| 14 | 05/11/2011 | D | Sassuolo | 0 | Torino | 0 | | (H) | 3rd | |
| 13 | 01/11/2011 | W | Modena | 2 | Sassuolo | 5 | | (H) | 3rd | |
| 12 | 29/10/2011 | W | Sassuolo | 1 | Grosseto | 0 | | (H) | 3rd | |
| 11 | 22/10/2011 | D | Empoli | 1 | Sassuolo | 1 |  | (H) | 4th | |
| 10 | 15/10/2011 | W | Sassuolo | 1 | Albinoleffe | 0 | | (H) | 3rd | |
| 9 | 09/10/2011 | D | Sampdoria | 1 | Sassuolo | 1 | | (H) | 3rd | |
| 8 | 05/10/2011 | D | Sassuolo | 1 | Pescara | 1 | | (H) | 4th | |
| 7 | 30/09/2011 | W | Varese | 0 | Sassuolo | 1 | | (H) | 4th | |
| 6 | 24/09/2011 | L | Sassuolo | 1 | Bari | 2 | | (H) | 6th | |
| 5 | 17/09/2011 | W | Ascoli | 0 | Sassuolo | 1 | | (H) | 1st | |
| 4 | 10/09/2011 | W | Sassuolo | 2 | Cittadella | 0 | | (H) | 3rd | |
| 3 | 04/09/2011 | L | Hellas Verona | 1 | Sassuolo | 0 | | (H) | 4th | |
| 2 | 30/08/2011 | W | Vicenza | 0 | Sassuolo | 1 | | (H) | 1st | |
| 1 | 27/08/2011 | W | Sassuolo | 3 | Nocerina | 1 | | (H) | 2nd | |
