| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 17 | 27/11/2011 | L | Zenit St Petersburg | 2 | Lokomotiv Moscow | 1 | ||||
| 16 | 20/11/2011 | L | Spartak Moscow | 2 | Lokomotiv Moscow | 0 | ||||
| 15 | 29/10/2011 | L | Spartak Moscow | 3 | Lokomotiv Moscow | 0 |  | (H) | 4th |  |
| 14 | 24/10/2011 | W | Spartak Nalchik | 1 | Lokomotiv Moscow | 2 | | (H) | 3rd | |
| 13 | 02/10/2011 | W | Anzhi Makhachkala | 0 | Lokomotiv Moscow | 1 | | (H) | 4th | |
| 12 | 18/09/2011 | W | Terek Groznyi | 0 | Lokomotiv Moscow | 4 | | (H) | 4th | |
| 11 | 28/08/2011 | W | Kuban Krasnodar | 0 | Lokomotiv Moscow | 1 | | (H) | 6th | |
| 10 | 14/08/2011 | D | Volga Nyzhnyi Novgorod | 0 | Lokomotiv Moscow | 0 | | (H) | 8th | |
| 9 | 31/07/2011 | W | FK Rostov | 0 | Lokomotiv Moscow | 3 | | (H) | 6th | |
| 8 | 26/06/2011 | L | Dinamo Moscow | 4 | Lokomotiv Moscow | 1 | | (H) | 8th | |
| 7 | 22/06/2011 | L | CSKA Moscow | 3 | Lokomotiv Moscow | 1 | | (H) | 6th | |
| 6 | 10/06/2011 | D | Tomsk | 2 | Lokomotiv Moscow | 2 | | (H) | 6th | |
| 5 | 20/05/2011 | D | Rubin Kazan | 0 | Lokomotiv Moscow | 0 | | (H) | 1st | |
| 4 | 08/05/2011 | D | Zenit St Petersburg | 1 | Lokomotiv Moscow | 1 | | (H) | 4th | |
| 3 | 23/04/2011 | W | Krasnodar | 1 | Lokomotiv Moscow | 4 | | (H) | 3rd | |
| 2 | 09/04/2011 | L | Krylya Sovetov | 1 | Lokomotiv Moscow | 0 |  | (H) | 12th | |
| 1 | 20/03/2011 | L | Amkar Perm | 1 | Lokomotiv Moscow | 0 | | (H) | 8th | |
