| Game | Date | Home Team | Away Team | Form | League Position | |||||
| 38 | 12/05/2012 | D | Real Betis | 2 | Barcelona | 2 |  | (H) | 12th |  |
| 37 | 05/05/2012 | L | Sporting Gijon | 2 | Real Betis | 1 | | (H) | 12th | |
| 36 | 02/05/2012 | W | Sevilla | 1 | Real Betis | 2 | | (H) | 11th | |
| 35 | 29/04/2012 | D | Real Betis | 2 | Atletico Madrid | 2 | | (H) | 14th | |
| 34 | 22/04/2012 | L | Valencia | 4 | Real Betis | 0 | | (H) | 13th | |
| 33 | 15/04/2012 | W | Real Betis | 1 | Osasuna | 0 | | (H) | 12th | |
| 32 | 10/04/2012 | D | Real Sociedad | 1 | Real Betis | 1 | | (H) | 14th | |
| 31 | 07/04/2012 | W | Real Betis | 3 | Villarreal | 1 | | (H) | 13th | |
| 30 | 31/03/2012 | W | Malaga | 0 | Real Betis | 2 | | (H) | 15th | |
| 29 | 25/03/2012 | D | Real Betis | 1 | Racing Santander | 1 | | (H) | 15th | |
| 28 | 22/03/2012 | D | Real Betis | 1 | Espanyol | 1 | | (H) | 15th | |
| 27 | 17/03/2012 | L | Rayo Vallecano | 3 | Real Betis | 0 | | (H) | 16th | |
| 26 | 10/03/2012 | L | Real Betis | 2 | Real Madrid | 3 | | (H) | 15th | |
| 25 | 05/03/2012 | L | Levante | 3 | Real Betis | 1 | | (H) | 12th | |
| 24 | 25/02/2012 | D | Real Betis | 1 | Getafe | 1 | | (H) | 12th | |
| 23 | 20/02/2012 | W | Real Zaragoza | 0 | Real Betis | 2 | | (H) | 12th | |
| 22 | 11/02/2012 | W | Real Betis | 2 | Athletic Bilbao | 1 | | (H) | 14th | |
| 21 | 04/02/2012 | L | Mallorca | 1 | Real Betis | 0 | | (H) | 16th | |
| 20 | 29/01/2012 | L | Real Betis | 1 | Granada | 2 | | (H) | 13th | |
| 19 | 21/01/2012 | D | Real Betis | 1 | Sevilla | 1 | | (H) | 12th | |
| 18 | 15/01/2012 | L | Barcelona | 4 | Real Betis | 2 | | (H) | 11th | |
| 17 | 08/01/2012 | W | Real Betis | 2 | Sporting Gijon | 0 |  | (H) | 10th | |
| 16 | 18/12/2011 | W | Atletico Madrid | 0 | Real Betis | 2 | | (H) | 11th | |
| 15 | 10/12/2011 | W | Real Betis | 2 | Valencia | 1 | | (H) | 14th | |
| 14 | 04/12/2011 | L | Osasuna | 2 | Real Betis | 1 | | (H) | 17th | |
| 13 | 27/11/2011 | L | Real Betis | 2 | Real Sociedad | 3 | | (H) | 14th | |
| 12 | 19/11/2011 | L | Villarreal | 1 | Real Betis | 0 | | (H) | 13th | |
| 11 | 05/11/2011 | D | Real Betis | 0 | Malaga | 0 | | (H) | 12th | |
| 10 | 30/10/2011 | L | Racing Santander | 1 | Real Betis | 0 | | (H) | 12th | |
| 9 | 27/10/2011 | L | Espanyol | 1 | Real Betis | 0 | | (H) | 10th | |
| 8 | 23/10/2011 | L | Real Betis | 0 | Rayo Vallecano | 2 | | (H) | 7th | |
| 7 | 15/10/2011 | L | Real Madrid | 4 | Real Betis | 1 | | (H) | 7th | |
| 6 | 02/10/2011 | L | Real Betis | 0 | Levante | 1 | | (H) | 7th | |
| 5 | 26/09/2011 | L | Getafe | 1 | Real Betis | 0 | | (H) | 1st | |
| 4 | 22/09/2011 | W | Real Betis | 4 | Real Zaragoza | 3 | | (H) | 1st | |
| 3 | 18/09/2011 | W | Athletic Bilbao | 2 | Real Betis | 3 | | (H) | 2nd | |
| 2 | 11/09/2011 | W | Real Betis | 1 | Mallorca | 0 | | (H) | 3rd | |
| 1 | 27/08/2011 | W | Granada | 0 | Real Betis | 1 | | (H) | 7th | |
